By G. C. Barrett
This article is meant for undergraduate and starting graduate scholars in chemistry and biochemistry learning amino acids and peptides. The authors be aware of amino acids and peptides with out targeted discussions of proteins, whereas giving all of the crucial heritage chemistry, together with series selection, synthesis and spectroscopic equipment. The procedure is meant to motivate the reader to move classical limitations whereas gaining an realizing of protein habit on a molecular point. The publication comprises chapters at the organic roles of amino acids, in addition to a bit on enzyme-catalyzed synthesis of peptides, with appropriate examples, a space usually overlooked in texts describing peptide synthesis. this contemporary textual content could be of worth within the amino acid, peptide and protein box, to complex undergraduates, graduate scholars and study employees.
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Additional resources for Amino Acids and Peptides (1998)
Analysis protocols may exploit other physical measurements, such as the titration of the phenolic hydroxy group to determine the number of tyrosine residues present in a peptide or protein, by following changes in UV spectra of a protein as a function of pH. Modern UV spectrometers may oﬀer the option of ﬁrst and second-derivative UV spectroscopy and measurements in the 240–320 nm range using these techniques can be interpreted to determine the ratios of the various aromatic residues in peptides.
1987) Int. J. Pept. , 29, 486. Chou, P. Y. and Fasman, G. D. (1974) Biochemistry, 13, 222. Fasman, G. D. (1985) J. , 8, 15. Fasman, G. D. (1989) Prediction of Protein Structures and the Principles of Protein Conformation, Plenum, New York. Fasman, G. D. ) (1996) Circular Dichroism in Conformational Analysis of Biomolecules, Plenum, New York. Hermkens, P. H. , van Dinther, T. , Joukema, C. , Wagenaars, G. N. and Ottenheijm, H. C. , 35, 9271. , Buttkus, U. -H. (1991) Angew. Chem. Int. , 30, 1514.
H. (1991) Angew. Chem. Int. , 30, 1514. Zimm, B. , and Bragg, J. K. (1959) J. Chem. , 31, 526. g. g. g. aliphatic hydroxy and side-chain amide groups). The properties of peptides also depend on the same factors, but it must be remembered that, in a linear peptide containing n amino-acid residues, all but one ␣-amino group and one ␣carboxy group are incorporated into neutral peptide and amide bonds. In a cyclic peptide, there are no free ␣-amino or ␣-carboxy groups. Moreover, some peptides contain groups such as carbohydrate, phosphate ester, lipids and porphyrins that further modify physical properties.
Amino Acids and Peptides (1998) by G. C. Barrett